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Carna Biosciences

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Serine/Threonine과 Tyrosine kinases에 대한 targeted cell-based assay로써 특정 kinase의 인산화 활성을 직접 정량할 수 있습니다.
제품 담당: 공민영 매니저
Tel. 070-4759-5522
Email. mykong@jcbio.co.kr

제품소개

0Screen and profile your kinase inhibitors directly in cells using ourClariCELL™ Kinase Cell-Based Assay Services, developed by Cell AssayInnovations, Inc. (MA, USA). The ClariCELL™ kinase assay platform is a uniquesystem that directly quantifies specific kinase phosphorylation activity in thephysiologically relevant context of human cells. It features transientexpression of full length kinases in HEK293 cells and quantification ofphosphorylation by conventional antibody-based detection. Utilize our availableassays for lead optimization, selectivity profiling, or mechanism of actionstudies, or contact us about customized assay development in singleplex ormultiplex format. Benefits of OurApproach § Cell-Based Assays forSerine/Threonine and Tyrosine Kinases § Direct Detection of PhosphorylationEvents Useful for primary screening, lead optimization, and selectivity profiling § Physiologically Relevant CellsExpressing Full Length Kinases § Multiplexing Capability Simultaneousmeasurement of targets of interest, including drug-resistant mutants § Flexibility Choice of kinase(s)and cells of interest §  CAI's ClariCELL™Kinase Cell-Based Assays Our approachfeatures transient expression of full length human kinase(s) of interest inhuman cells, then quantification of protein substrate phosphorylation levels byconventional antibody-based detection. Unlike other systems, these assays aredesigned to be specific to the target of interest, allowing for selectivity andmechanism of action studies, in addition to potency determinations. Our streamlinedprocessing also allows for dramatically reduced assay development time andaffordable screening rates. CAI's ClariCELL™Kinase Cell-Based Assays & Kits Tyrosine Kinases Name of Kinase ClariCELL™ Assay Service ClariCELL™ Assay Kit       Availability Format CAI's Cat No.       ABL1 ○(datasheet) ○ 96-well ELISA CK-01-1010       ABL1 [E255V] ○(datasheet) ○ 96-well ELISA CK-01-1011       ABL1 [T315I] ○(datasheet) ○ 96-well ELISA CK-01-1012       BTK ○(datasheet) ○(manual) 96-well ELISA CK-01-1001       ○(manual) 384-well ELISA CK-01-1001-384       BTK [C481S] ○(datasheet) ○(manual) 96-well ELISA CK-01-1002       ○(manual) 384-well ELISA CK-01-1002-384       BTK [T474A] ○(datasheet) ○ 96-well ELISA CK-01-1003       384-well ELISA CK-01-1003-384       BTK [T474M] ○(datasheet) ○ 96-well ELISA CK-01-1004       384-well ELISA CK-01-1004-384       BMX ○(datasheet) ○ 96-well ELISA CK-01-1330       EphB4 ○(datasheet) ○ 96-well ELISA CK-01-1020       FGFR1 ○(datasheet) ○ 96-well ELISA CK-01-1030       HCK ○(datasheet) ○ 96-well ELISA CK-01-1360       HER2 ○(datasheet) ○ 96-well ELISA CK-01-1420       ITK ○(datasheet) ○ 96-well ELISA CK-01-1370       ITK (mouse) ○(datasheet) ○ 96-well ELISA CK-01-1371       JAK1 ○(datasheet) ○ 96-well ELISA CK-01-1050       JAK2 ○(datasheet) ○ 96-well ELISA CK-01-1060       JAK2 [V617F] ○(datasheet) ○ 96-well ELISA CK-01-1061       JAK3 ○(datasheet) ○ 96-well ELISA CK-01-1070       JAK3 [Y981F] ○(datasheet) ○ 96-well ELISA CK-01-1071       KDR (VEGFR2) ○(datasheet) ○ 96-well ELISA CK-01-1040       LCK ○(datasheet) ○ 96-well ELISA CK-01-1080       TEC ○(datasheet) ○ 96-well ELISA CK-01-1090       TXK ○(datasheet) ○ 96-well ELISA CK-01-1440       TYK2 ○(datasheet) ○ 96-well ELISA CK-01-1170         Serine/Threonine Kinases Name of Kinase ClariCELL™ Assay Service ClariCELL™ Assay Kit       Availability Format CAI's Cat No.       AKT1 ○(datasheet) ○ 96-well ELISA CK-01-1100       DCLK2 ○(datasheet) ○ 96-well ELISA CK-01-1470       DYRK1A ○(datasheet) ○ 96-well ELISA CK-01-1110       MST1 ○(datasheet) ○ 96-well ELISA CK-01-1120       PDK1 ○(datasheet) ○ 96-well ELISA CK-01-1130       PIM1 ○(datasheet) ○ 96-well ELISA CK-01-1140       PIM2 ○(datasheet) ○ 96-well ELISA CK-01-1150       PIM3 ○(datasheet) ○ 96-well ELISA CK-01-1160        

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