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Carna Biosciences

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Serine/Threonine과 Tyrosine kinases에 대한 targeted cell-based assay로써 특정 kinase의 인산화 활성을 직접 정량할 수 있습니다.
제품 담당:
황찬영 과장 (영업부), cyhwang@jcbio.co.kr, Tel. 010-8311-2333
공민영 과장 (학술부), mykong@jcbio.co.kr, Tel. 02-6677-1063

제품소개

0Screen and profile your kinase inhibitors directly in cells using ourClariCELL™ Kinase Cell-Based Assay Services, developed by Cell AssayInnovations, Inc. (MA, USA). The ClariCELL™ kinase assay platform is a uniquesystem that directly quantifies specific kinase phosphorylation activity in thephysiologically relevant context of human cells. It features transientexpression of full length kinases in HEK293 cells and quantification ofphosphorylation by conventional antibody-based detection. Utilize our availableassays for lead optimization, selectivity profiling, or mechanism of actionstudies, or contact us about customized assay development in singleplex ormultiplex format.

CAI & CARNA BIOSCIENCES

Benefits of OurApproach

§ Cell-Based Assays forSerine/Threonine and Tyrosine Kinases

§ Direct Detection of PhosphorylationEvents Useful for primary screening, lead optimization, and selectivity profiling

§ Physiologically Relevant CellsExpressing Full Length Kinases

§ Multiplexing Capability Simultaneousmeasurement of targets of interest, including drug-resistant mutants

§ Flexibility Choice of kinase(s)and cells of interest

§  CAI's ClariCELL™Kinase Cell-Based Assays

Our approachfeatures transient expression of full length human kinase(s) of interest inhuman cells, then quantification of protein substrate phosphorylation levels byconventional antibody-based detection. Unlike other systems, these assays aredesigned to be specific to the target of interest, allowing for selectivity andmechanism of action studies, in addition to potency determinations.

Our streamlinedprocessing also allows for dramatically reduced assay development time andaffordable screening rates.

CAI's ClariCELL™Kinase Cell-Based Assays & Kits

Tyrosine Kinases

Name of Kinase

ClariCELL™
Assay
Service

ClariCELL™ Assay Kit

     

Availability

Format

CAI's Cat No.

     

ABL1

○(datasheet)

96-well ELISA

CK-01-1010

     

ABL1 [E255V]

○(datasheet)

96-well ELISA

CK-01-1011

     

ABL1 [T315I]

○(datasheet)

96-well ELISA

CK-01-1012

     

BTK

○(datasheet)

○(manual)

96-well ELISA

CK-01-1001

     

○(manual)

384-well ELISA

CK-01-1001-384

     

BTK [C481S]

○(datasheet)

○(manual)

96-well ELISA

CK-01-1002

     

○(manual)

384-well ELISA

CK-01-1002-384

     

BTK [T474A]

○(datasheet)

96-well ELISA

CK-01-1003

     

384-well ELISA

CK-01-1003-384

     

BTK [T474M]

○(datasheet)

96-well ELISA

CK-01-1004

     

384-well ELISA

CK-01-1004-384

     

BMX NEW

○(datasheet)

96-well ELISA

CK-01-1330

     

EphB4

○(datasheet)

96-well ELISA

CK-01-1020

     

FGFR1

○(datasheet)

96-well ELISA

CK-01-1030

     

HCK NEW

○(datasheet)

96-well ELISA

CK-01-1360

     

HER2

○(datasheet)

96-well ELISA

CK-01-1420

     

ITK

○(datasheet)

96-well ELISA

CK-01-1370

     

ITK (mouse)

○(datasheet)

96-well ELISA

CK-01-1371

     

JAK1

○(datasheet)

96-well ELISA

CK-01-1050

     

JAK2

○(datasheet)

96-well ELISA

CK-01-1060

     

JAK2 [V617F]

○(datasheet)

96-well ELISA

CK-01-1061

     

JAK3

○(datasheet)

96-well ELISA

CK-01-1070

     

JAK3 [Y981F]

○(datasheet)

96-well ELISA

CK-01-1071

     

KDR (VEGFR2)

○(datasheet)

96-well ELISA

CK-01-1040

     

LCK

○(datasheet)

96-well ELISA

CK-01-1080

     

TEC

○(datasheet)

96-well ELISA

CK-01-1090

     

TXK

○(datasheet)

96-well ELISA

CK-01-1440

     

TYK2

○(datasheet)

96-well ELISA

CK-01-1170

     

 

Serine/Threonine Kinases

Name of Kinase

ClariCELL™
Assay
Service

ClariCELL™ Assay Kit

     

Availability

Format

CAI's Cat No.

     

AKT1

○(datasheet)

96-well ELISA

CK-01-1100

     

DCLK2

○(datasheet)

96-well ELISA

CK-01-1470

     

DYRK1A

○(datasheet)

96-well ELISA

CK-01-1110

     

MST1

○(datasheet)

96-well ELISA

CK-01-1120

     

PDK1

○(datasheet)

96-well ELISA

CK-01-1130

     

PIM1

○(datasheet)

96-well ELISA

CK-01-1140

     

PIM2

○(datasheet)

96-well ELISA

CK-01-1150

     

PIM3

○(datasheet)

96-well ELISA

CK-01-1160

     

 


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